Digital Outcomes and Biomarkers
Advancing Clinical Insights Through Digital Measurement
Digital health technologies (DHTs) enable more precise, real-world assessment of patient function across a variety of measurement domains. The Ametris technology platform transforms raw sensor data into high-quality digital measures of physical activity, sleep, mobility, vital signs, and more using an advanced suite of validated, ready-to-deploy algorithms.
Sleep
Sleep is a critical focus of clinical research both as a primary disorder and as a symptom of many diseases. Continuous, real-world sleep assessment provides a more comprehensive understanding of sleep quality and health.
Physical Activity
Physical activity and overall functioning are key indicators of health across many chronic conditions. Objective, continuous activity data offers a more reliable view of daily behaviors and their relationship to clinical outcomes.
Gait and Mobility
Gait and mobility impairments are common in many chronic diseases and contribute to fall risk. Digital mobility measures can detect subtle changes in walking patterns and provide predictive insight into future falls.
Vital Signs
Remote, continuous monitoring of vital signs, such as heart rate, respiration, and temperature, enables earlier detection of changes in physiologic status and provides deeper insights into patient health over time.
Cardinal Symptoms
Digitally capturing cardinal symptoms linked to chronic diseases enhances measurement precision. Continuous symptom tracking supports a better understanding of disease progression and treatment responses.
Relevance of Algorithms and Measures
The table below indicates the relevance of these measures across a range of conditions.
| THERAPEUTIC AREA | INDICATION | PHYSICAL ACTIVITY | SLEEP | MOBILITY | UPPER LIMB | FALL | TREMOR | SCRATCH | VITAL SIGNS / CRS EARLY WARNING (LEAP) |
| Oncology |
Cancers | ||||||||
| Cachexia | |||||||||
| Neurology | Alzheimer's/ Dementia | ||||||||
| Parkinson's Disease | |||||||||
| Multiple Sclerosis | |||||||||
| ALS | |||||||||
| DMD | |||||||||
| SMA | |||||||||
| Rheumatology | Myositis | ||||||||
| Arthritis | |||||||||
| Respirology | COPD | ||||||||
| Pulmonary Hypertension | |||||||||
| Cardiology | Heart Failure | ||||||||
| Psychiatry | Depression | ||||||||
| Schizophrenia | |||||||||
| Dermatology | Atopic Dermatitis | ||||||||
| Psoriasis |
More check marks = Greater relevancy