Resources

Therapeutic Area	Indication	Most Significant Symptoms Reported by Patients	Meaningful Aspects of Health	Candidate Digital Measures	Digital Measures Report
Neurology	Parkinson's Disease	Motor Symptoms Cognitive Dysfunction Sleep Disturbances	Cardinal Symptoms Sleep	Bradykinesia Score Dyskinesia Score Percent Time Tremor Wake after sleep onset	View Report
Cardiology	Hypertrophic Cardiomyopathy (HCM)	Shortness of Breath or Trouble Breathing Exercise Intolerance Lightheadedness, Dizziness, Fainting Arrhythmias / Heart Palpitations	Physical Activity Gait and Mobility Vital Signs	Non-sedentary time Walking bouts Walking speed Arrhythmia burden	View Report
Dermatology	Atopic Dermatitis (Eczema)	Itchiness Red, Inflamed Skin Pain Sleep Disturbances	Scratch Sleep	Wake after sleep onset Total scratch time	View Report
Respirology	Idiopathic Pulmonary Fibrosis (IPF)	Coughing Shortness of Breath Fatigue	Physical Activity Cough	Moderate-to-vigorous physical activity Non-sedentary time Step count Cough	View Report
Respirology	Obstructive Sleep Apnea (OSA)	Fatigue and Daytime Sleepiness Unrefreshing Sleep Cognitive Issues	Physical Activity Sleep Vital Signs	Non-sedentary time Wake after sleep onset Night time oxygen saturation	View Report
Cardiology	Pulmonary Arterial Hypertension (PAH)	Shortness of Breath Fatigue	Physical Activity Gait and Mobility	Moderate-to-vigorous physical activity Non-sedentary time Walking bouts Walking speed	View Report
Dermatology	Psoriasis	Itching Flaking or Scaling Skin Dry, Cracked Skin that may bleed Stinging, Burning, and/or Pain	Scratch Sleep Physical Activity	Wake after sleep onset Total scratch time Step count Non-sedentary time	View Report
Neurology	Narcolepsy	Excessive Daytime Sleepiness Cataplexy Sleep Dysfunction Cognitive Effects and Automatic Behaviors	Physical Activity Sleep Vital Signs	Non-sedentary time Wake after sleep onset Daytime immobility bouts	View Report
Respirology	Asthma	Shortness of Breath or Trouble Breathing Frequent Coughing Chest Tightness Mood changes	Physical Activity Sleep Cough	Moderate-to-vigorous physical activity Non-sedentary time Step count Wake after sleep onset Cough	View Report
Rheumatology	Osteoarthritis (OA)	Pain and Tenderness Stiffness Functional Limitations and Impaired Mobility Fatigue and Sleep Disturbances	Physical Activity Sleep Gait and Mobility	Moderate-to-vigorous physical activity Non-sedentary time Step count Walking bouts Walking speed Wake after sleep onset	View Report
Oncology	Cancer Cachexia	Muscle Weakness Fatigue/Feelings of Tiredness Loss of Appetite Severe Weight Loss	Physical Activity Gait and Mobility	Moderate-to-Vigorous Physical Activity Non-Sedentary Time Walking bouts Walking speed	View Report
Neurology	Myotonic Dystrophy (DM)	Muscle Weakness and Myotonia Fatigue Pain Heart Problems	Physical Activity Gait and Mobility Sleep Vital Signs	Non-Sedentary Time Step Count Walking Bouts Walking Speed / Cadence Wrist 6 Minute Peak Activity Specific Wrist Movement Metrics Wake After Sleep Onset Arrhythmia Burden	View Report
Neurology	Spinal Muscular Atrophy (SMA)	Fatigue Muscle Weakness and Loss of Mobility Breathing Difficulties	Physical Activity Gait and Mobility	Non-Sedentary Time Step Count Walking Bouts Walking Speed Wrist 6 Minute Peak Activity Specific Wrist Movement Metrics	View Report
Neurology	Kennedy’s Disease (KD) / Spinal and bulbar muscular atrophy (SBMA)	Muscle Weakness and Cramping Fatigue Breathing Difficulties Balance Issues	Physical Activity Gait and Mobility	Non-Sedentary Time Walking Bouts Walking Speed / Cadence	View Report
Neurology	Amyotrophic Lateral Sclerosis (ALS)	Muscle Weakness and Fatigue Shortness of Breath Difficulty Sleeping Speech Problems	Physical Activity Gait and Mobility Sleep Speech	6 Minute Peak Activity Walking Bouts Walking Speed / Cadence Step Counts Specific Wrist Movement Metrics	View Report
Neurology	Huntington's Disease	Cognitive Impairment Chorea and other Motor Symptoms Depression or Anxiety	Physical Activity Gait and Mobility Chorea Sleep	Total Activity Counts Walking Bouts Walking Speed / Cadence Step Counts Wrist Activity Counts Dyskinesia Score	View Report
Neurology	Sarcopenia	Muscle Loss, Muscle Weakness, Frailty Balance Problems and Falling Fatigue Muscle Pain	Physical Activity Gait and Mobility Sleep	Moderate-to-Vigorous Physical Activity Non-Sedentary Time Walking bouts Walking speed	View Report
Rheumatology	Systemic Sclerosis	Painful cold sensitivity Gastrointestinal symptoms Chronic Fatigue Contractures and Calcinosis of Digits	Physical Activity Sleep	Non-sedentary time Wake after sleep onset	View Report
Rheumatology	Inclusion Body Myositis (IBM)	Muscle Weakness and Atrophy Dysphagia Fatigue	Physical Activity Sleep Gait and Mobility	Moderate-to-Vigorous Physical Activity Non-Sedentary Time Step count Walking speed Wake after sleep onset	View Report
hematology	Hemophilia	Joint Damage and Pain Bleeding	Physical Activity Gait and Mobility	Moderate-to-Vigorous Physical Activity (MVPA) Non-Sedentary Time Step Count Walking Bouts Walking Speed	View Report
Metabolic and Endocrinology	Nonalcoholic Steatohepatitis (NASH)	Fatigue / Low Energy Abdominal Pain	Physical Activity Gait and Mobility	Moderate-to-Vigorous Physical Activity Non-Sedentary Time Walking bouts	Coming Soon
Oncology	Lung Cancer	Fatigue Breathing Difficulties and Shortness of Breath Chronic Pain Persistent Cough	Physical Activity Sleep Cough	Moderate-to-Vigorous Physical Activity Non-Sedentary Time Step Count Wake After Sleep Onset Cough Frequency	View Report
Oncology	Breast Cancer	Fatigue and weakness Pain Depression or Anxiety	Physical Activity Sleep	Moderate-to-Vigorous Physical Activity Non-Sedentary Time Step Count Wake After Sleep Onset	View Report
Oncology	Low-Grade Serous Ovarian Cancer	Fatigue Bone / Pelvic Pain Depression or Anxiety	Physical Activity Gait and Mobility Sleep	Moderate-to-Vigorous Physical Activity Non-Sedentary Time Step Count Walking Bouts Wake After Sleep Onset	View Report
Oncology	Xerostomia	Eating Challenges Fatigue and Sleep Disruption	Sleep Cough	Total Sleep Time Wake After Sleep Onset Cough Frequency	View Report
Oncology	Reducing Cardiac Late Effects in Pediatric Cancer Survivors	Shortness of Breath Exercise Intolerance Fatigue	Physical Activity Gait and Mobility Vital Signs	Moderate-to-Vigorous Physical Activity (MVPA) Non-Sedentary Time Step Count Walking Bouts Arrhythmia Burden	View Report
Respirology	Cystic Fibrosis	Pulmonary Exacerbations/Infections Excessive Cough Gastrointestinal Symptoms Fatigue	Physical Activity Sleep Cough	Moderate-to-Vigorous Physical Activity (MVPA) Non-Sedentary Time Wake After Sleep Onset Cough Frequency	View Report
Respirology	Non-Tuberculous Mycobacterial (NTM) Lung Infection	Coughing Fatigue Shortness of Breath	Physical Activity Sleep Cough	Moderate-to-Vigorous Physical Activity (MVPA) Non-Sedentary Time Wake After Sleep Onset Cough Frequency	View Report
Dermatology	Primary Biliary Cholangitis	Fatigue Musculoskeletal Pain Itchy Skin (Pruritus)	Physical Activity Sleep Nocturnal Scratch	Moderate-to-Vigorous Physical Activity (MVPA) Non-Sedentary Time Total Sleep Time Wake After Sleep Onset Total Scratching Time Scratch Counts / Frequency	View Report
Dermatology	Primary Sclerosing Cholangitis	Fatigue Itching (Pruritus) Pain	Physical Activity Sleep Nocturnal Scratch	Moderate-to-Vigorous Physical Activity (MVPA) Non-Sedentary Time Total Sleep Time Wake After Sleep Onset Total Scratching Time Scratch Counts / Frequency	View Report

White Paper

Crossing the Chasm: Real-World Value Realized from DHTs in Clinical Trials

Here, we’ve collected 4 real-world examples of clinical trials that incorporated DHTs. We assess the aspect of clinic...

White Paper

Maximize Your R&D Investment in DHTs Through the Collection and Retention of Raw Sensor Data

Sensor-based digital health technologies (DHTs) have revolutionized the ability to remotely obtain and analyze clinic...

White Paper

What Does the New FDA DHT Guidance Mean? A Practical Guide for Sponsors

In December 2021, the FDA released its first guidance specific to the use of digital health technologies (DHTs).

eBook

A Guide to Wearable-Enabled Digital Clinical Measures in Neuroscience eBook

Neurological diseases are inherently complex, and drug development in neurology is notoriously challenging.

White Paper

Objective Scratch Assessments Using Digital Health Technologies (DHTs)

Scratching an itch can result in further problems such as inflammation and lesions that, in turn...

White Paper

Understanding Usability: Guidance for Gathering Complete, Unbiased Data from Wearables

Usability is critical to wearable-enabled clinical trials, which is why the FDA calls usability...

White Paper

How Actigraphy is Clearing Operational Barriers to Decentralized Trials

In this ActiGraph white paper, we cover the operational challenges of DCTs and how actigraphy is being used to clear ...

Maximize Your R&D Investment in DHTs Through the Collection and Retention of Raw Sensor Data

June 26, 2022

Sensor-based digital health technologies (DHTs) have revolutionized the ability to remotely obtain and analyze clinically relevant information from clinical trial participants. Through ActiGraph’s 20 years of experience supporting clinical research, we’ve learned that a key factor of success when using DHTs for clinical ...

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What Does the New FDA DHT Guidance Mean? A Practical Guide for Sponsors

June 9, 2022

In December 2021, the FDA released its first guidance specific to the use of digital health technologies (DHTs). This marked an important milestone, signifying willingness from regulators to adopt new digital clinical measurements. In this ActiGraph white paper, we've synthesized the FDA's guidance into a practical, actionable ...

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Objective Scratch Assessments Using Digital Health Technologies (DHTs)

May 16, 2022

Scratching an itch can result in further problems such as inflammation and lesions that, in turn, cause more itch. Often leading to a vicious scratch-itch cycle, the compulsion to scratch negatively affects the quality of life of millions of people.

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Understanding Usability: Guidance for Gathering Complete, Unbiased Data from Wearables

April 21, 2022

Usability is critical to wearable-enabled clinical trials, which is why the FDA calls usability testing a “critical component” of deploying digital technologies. When approaching usability, multiple characteristics need to be taken into consideration for each stakeholder, starting with participants who interact directly with the device.

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How Actigraphy is Clearing Operational Barriers to Decentralized Trials

March 10, 2022

In this ActiGraph white paper, we cover the operational challenges of DCTs and how actigraphy is being used to clear those barriers.

Download Now

A Guide to Wearable-Enabled Digital Clinical Measures in Neuroscience eBook

February 4, 2022

Neurological diseases are inherently complex, and drug development in neurology is notoriously challenging. The imprecision of both disease diagnosis and symptom monitoring presents additional hurdles for clinical development.

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Reimagining Oncology Clinical Trials with Digital Biomarkers

December 6, 2021

Health metrics enabled by wearables are a huge untapped opportunity in oncology clinical trials. In this paper, we look at the perceived barriers to the adoption of wearables—and the major benefits that await sponsors that overcome them.

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Measuring Real-World Sleep with Actigraphy: Three ActiGraph Use Cases

December 2, 2021

In this white paper, we present three use cases for collecting actigraphy-derived sleep measures during an interventional clinical trial.

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Clinical Data Capture eBook

June 9, 2022

As the capabilities of wearable technologies continue to advance and the decentralization of clinical trials has become a mission-critical objective for many sponsor organizations, conventional methods of data collection must evolve to meet this changing industry landscape.

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How Future Proof Is Your Digital Biomarker Data? Considerations for maximizing the long-term value of wearable sensor data

March 8, 2021

When evaluating wearable motion-sensing technologies for clinical research, there are a myriad of factors to consider, including battery life, storage capacity, data access, validation, patient acceptance, privacy, and regulatory clearance, to name a few.

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Actigraphy Monitoring Wearables in Clinical Trials: Overcoming Barriers to Adoption & Strategies for Successful Technology Implementation

March 13, 2018

In this white paper, ActiGraph experts discuss several common perceived barriers to actigraphy adoption and identify strategies to help sponsors develop a successful technology implementation plan and navigate the common challenges that can derail any mHealth data collection initiative, including: Data quality and meaningful interpretation Adoption costs and uncertain ROI ...

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Scaling and Correcting Accelerometer Data Affected by 16CPAN03

November 8, 2016

In March of 2016, ActiGraph identified an issue that caused a data anomaly (raw data attenuation) on wGT3X-BT activity monitor units shipped between November 7, 2013 and March 24, 2014 which had collected data with firmware versions 1.4.0, 1.4.1, 1.5.0, 1.6.0 or 1.7.0. In order to minimize the impact on academic publications which rely on data from these units, ...

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ActiGraph White Paper: IMU Data

May 5, 2015

ActiGraph has recently released the ActiGraph GT9X Link, which contains an Inertial Measurement Unit (IMU). The IMU sensors and data output units of measure are listed in Table 1 below.

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ActiGraph White Paper: Accelerometer Technologies, Specifications, and Limitations

August 1, 2013

Technology advances and manufacturing efficiency improvements have drastically increased the options and flexibility available to users of accelerometer-based products. These advancements have led to confusion among activity monitor users, and many have been led to believe that device output normalization is an obvious and easy step. In truth, there are ...

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ActiGraph White Paper: Low Frequency Extension Filter

January 25, 2012

ActiGraph's new low frequency extension filter option now allows users to capture data previously unavailable. By adjusting filter criteria to allow more data to be retained in low activity and/or low frequency environments, elderly or other slow moving subjects can be studied. This filter significantly improves response to both ...

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ActiGraph White Paper: Actigraphy Sleep Scoring Algorithms

August 26, 2010

At present there are two algorithms that are primarily used to perform sleep scoring on actigraphy data captured by ActiGraph devices. These are the Cole-Kripke1 algorithm and the Sadeh2 algorithm.

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ActiGraph White Paper: Estimating Human Position with the ActiGraph GT3X Triaxial Activity Monitor

March 13, 2009

With the introduction of 3-axis accelerometers, it is now possible to expand beyond gross measurement of physical activity and classify activity types. The ActiGraph GT3X Triaxial Activity Monitor takes a first step in this direction with an inclinometer feature that indicates whether a subject is standing, sitting or lying ...

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ActiGraph White Paper: What is a Count?

May 19, 2008

ActiGraph routinely fields questions and inquiries regarding the definition of a ‘count’, the unit of measure for activity for ActiGraph’s monitors. Users are concerned about the ambiguity of this term and how it relates to the physical world. Although the origin of the term ‘count’ is unknown in its ...

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View all

November 1, 2023

LEAP Into the Future of Patient-Centered Research: Introducing the Latest Innovation in Wearable Technology

Watch this exclusive webinar as we unveil the ActiGraph LEAP™, our latest innovation in wearable digital health techn...

August 29, 2023

Advancing Heart Failure Research with Digital Measures

This 1-hour webinar explores how sensor-based digital health technologies (DHTs) can be used to collect clinically me...

April 1, 2023

Accelerating Rare Disease Drug Development with Wearable Digital Health Technologies

More than 90% of rare diseases do not have any treatment, representing a substantial unmet need for patients.

January 18, 2023

Enabling Fit-For-Purpose Algorithms for DHTs: Practical Considerations and Validation Update

Digital transformation in healthcare and clinical research has been slower to progress than in other economic sectors...

Recent Webinars

Watch previously recorded webinar discussions with industry leaders, who share their expertise in digital health technologies.

All Webinars

LEAP into the Future of Patient-Centered Research: Introducing the Latest Innovation in Wearable Technology

November 1, 2023

View details

Advancing Heart Failure Research with Digital Measures

August 29, 2023

View details

Accelerating Rare Disease Drug Development with Wearable Digital Health Technologies

April 26, 2023

View details

clinical research

ActiGraph Rebrands as Ametris to Reflect Expanded Clinical Evidence Generation Capabilities

New company name and visual identity represent a strategic focus on improved precision at every phase of clinical develo...

clinical research

ActiGraph Joins CHDI Foundation Data-Collection Initiative at Annual Huntington’s Disease Patient-Advocacy Conference

PENSACOLA, FL, Tuesday, June 24th, 2025 - ActiGraph, a leading provider of wearable technology and scientific services f...

clinical research

ActiGraph and ZEPHYRx Announce Partnership Expanding Remote Monitoring in Respiratory Trials

PENSACOLA, FL, May 15, 2025 - ActiGraph, a leading provider of wearable technology and scientific services for clinical ...

decentralized clinical trials

ActiGraph and Xincere Partner to Advance the Adoption of DHTs

PENSACOLA, FL, April 9, 2025 -ActiGraph, a leading provider of wearable technology and scientific services for clinical ...

digital clinical measures

ActiGraph Accelerates Clinical Trial Modernization with Transformational Acquisition of Biofourmis Life Science Business

PENSACOLA, FL, January 7, 2025 -ActiGraph, the global leader in wearable digital health technology for clinical research...

digital clinical measures

ActiGraph and Hyfe Announce Availability of New Digital Health Tool for Cough Monitoring

PENSACOLA, FL, January 28, 2025 -ActiGraph, the global leader in wearable digital health technology for clinical researc...

Algorithm

Continuous Cough Monitoring: Addressing Placebo Effects and Data Gaps in Clinical Studies

With traditional clinical research methods, we’re often limited to the “tip of the iceberg” when it comes to understandi...

wear compliance

Case Study: Evaluating and Selecting Digital Measures in Large-Scale Population Studies

Sensor-based DHTs offer a new opportunity to collect data for novel outcome measures in public health research in an obj...

sleep

Now Available: Digital Measurement of Nocturnal Scratch in Atopic Dermatitis

One of the most significant challenges in managing atopic dermatitis (AD) is the lack of objective measures to evaluate ...

sleep

ActiGraph Chosen to Support Wearable Data Collection for NHANES 2027 Cohort

ActiGraph, the leading provider of wearable digital health solutions, is excited to share that we have been selected by ...

oncology

The Pathway to a Digital Health Solution for Cytokine Release Syndrome Detection and Prediction

In this article, I’m excited to dive into the opportunities and challenges in the field of immunotherapy treatments, and...

clinical research

Reflecting on a Year of Transformative Advancements in Digital Health

As we embark on another exciting year for the digital health landscape, I wanted to take a moment to reflect on the stri...

CONFERENCE

American Academy of Dermatology (AAD)

March 8, 2024

10:00 AM

San Diego, CA

ActiGraph representatives will be attending this event. Please contact meetings@theactigraph.com to schedule a meeting.

Educational

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